Genentech Research/Sr. Research Associate - Cell Therapy Process Development in South San Francisco, California,
Research/Sr. Research Associate - Cell Therapy Process Development
South San Francisco, California
Job ID: 202102-104352 (http://jobs.gene.com/202102-104352)
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Genentech is seeking an exceptional, highly motivated, and talented cell biologist to support the cell therapy process development group, aiming to derive immune cells from induced pluripotent stem cells (iPSCs) for cell therapy applications. In this role, the successful candidate will work with internal and external colleagues to support pre-clinical and clinical process development and product characterization. The successful applicant will have a background in stem cell biology, iPSC maintenance and differentiation, flow cytometry, and molecular biology. Knowledge of the hematopoietic system and immunology is preferred.
iPSC culture and maintenance.
Differentiation of iPSCs into mature and functional immune cells.
Assess iPSC-derived cell products by cell-type-specific marker expression & functional characterization.
Interact with research and development teams to troubleshoot existing differentiation methods.
Evaluate platform technologies and instrumentation for internal use or potential outsourcing opportunities.
Ability to work with novel cell culture, iPSC reprogramming, and next-generation differentiation protocols to increase yield and process robustness.
Provide high-quality, specialized iPSC-derived cells to other scientists working on assay development and quality control.
Maintain accurate records of research and deliver scientific presentations and reports internally to interdisciplinary teams.
Occasional weekend and/or evening hours as necessary
B.S./M.S. + 1-2 years of relevant experience in cell biology, stem cell biology, molecular biology, immunology, bioengineering, or a related discipline.
Extensive hands-on mammalian cell culture experience is required.
Experience with multi-color flow cytometry.
Experience with mammalian cell culture and culturing primary cells, ESCs, iPSCs, in-vitro differentiation of ESC/iPSCs. 3D culture and differentiation of iPSCs is a plus.
Hands-on experience with iPSC differentiation to CD34+ hematopoietic progenitor cells or T cells is preferred.
Experience in process development, scaling, automation in a cell culture/production environment is a plus.
Excellent teamwork, oral/written communication, time management, analytical, critical thinking, and organizational skills.
High scientific integrity, committed to ethics and scientific rigor.
Who We Are
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.
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