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Bristol Myers Squibb Scientist in Devens, Massachusetts

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together and driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives. Bristol-Myers Squibb has expanded its large-scale biologics manufacturing facility in Devens, Massachusetts. The expansion has created a biologics center of excellence through the introduction of biologics development and clinical manufacturing capabilities to the site. Both represent new capabilities for Devens, a site that in its early years has focused solely on large-scale, bulk biologics manufacturing.

The Scientist will assume responsibilities in carrying out various projects including new technology development, rapid analytical method development, automation and process development (PD) support. The PD support includes analytical testing using separation methods (HPLC, UPLC, CE, iCE etc.) and spectroscopic techniques such as FTIR & Raman as well as providing TCAN based small-scale purification of bioreactor samples. The method development role will involve developing rapid methods using emerging technologies for on-line and off-line analysis of in-process samples. The new technology implementation consists of development and implementation on-line separation methods and sensor based technologies. Scope of method development includes evaluation, optimization and Design of Experiments (DOE) to establish robust techniques to support PD. The successful candidate will work closely with Process Development Group to align with their testing needs. The Scientist is expected to take active role in the planning and execution of small-scale protein purification as well as analytical method development and testing. The scientist will be engaged in spectroscopic analysis and modeling using FTIR and Raman spectroscopy. The Scientist will be responsible for generating and managing high quality analytical data.

The successful candidate will have excellent communication skills, be a team player, and have experience in LC and CE base separation methods as well as other spectroscopic techniques such as FTIR and Raman. Expertise in Biological Mass Spectrometry is highly desirable. The candidate will help to establish data trending and assay maintenance programs.

Responsibilities:

  • Provide analytical support to CHO derived monoclonal antibodies, fusion proteins, bispecific & tri-specific antibodies, E.coli derived recombinant proteins, etc.

  • Work in a matrix environment by collaborating with Process Development and Manufacturing Science & Technology group as well as other functional groups. .

  • Contribute analytical perspective to PD design of experiments and AS&T study protocols.

  • Provide analytical support for process performance qualification

Qualifications:

The successful candidate will have

  • A degree in Analytical Chemistry or Chemical Engineering discipline or equivalent

  • PhD with 1-2 years or MS with 4+ years or BS with 6+ years of relevant experience in Biopharmaceutical or Pharmaceutical industry.

  • A strong background in the areas of analytical chemistry/Chemical Engineering with strong emphasis on experience and working knowledge of Analytical techniques including HPLC, CE, iCE, FTIR, RAMAN, Mass Spectrometry, etc.

  • Works independently and as part of a matrix organization

Former experience providing analytical testing support to process development group is a plus. Small scale purification experience is highly desirable. The successful candidate will have excellent communication skills, be a team player, and have in-depth and broad experience in analytical techniques as they apply to Biologics Product Quality and related process impurities.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol Myers Squibb

Req Number: R1533494

Updated: 2021-04-17 09:10:06.310 UTC

Location: Devens,Massachusetts

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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