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Nationwide Children's Hospital IGM Sr. Bioinformatics Scientist - IGM- Dr. Wagner's Lab in Columbus, Ohio

Sr. Bioinformatics Scientist - RI IGM Wagner

The Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital is creating a future that integrates genomics into the everyday practice of pediatrics. Led by a team of internationally renowned genomic medicine scientists, the IGM is housed in the campus’ newest research building, spanning 25,000 square feet of laboratory and office space in a highly interactive setting. The Wagner Lab at IGM is looking for a senior bioinformatics scientist to lead the characterization of genomic knowledge and its application to tertiary analysis of genomic variation. Research efforts will include applying structured genomic knowledge to procedurally match, aggregate, and prioritize clinical evidence associated with molecular variation detected in the IGM sequencing analysis pipelines. The goal of this research is to create semantically rich and computable knowledge amenable to machine learning and clinical decision support algorithms.

Schedule: (Full time, Benefits Eligible)


Research III

700 Children's Dr

Columbus, OH 43205

Why Nationwide Children’s Hospital

The moment you walk through our doors, you can feel it. When you meet one of our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it, too. Welcome to Nationwide Children’s Hospital, where Passion Meets Purpose.

Here, Everyone Matters. We’re 14,000 strong. And it takes every single one of us to improve the lives of the kids we care for, and the kids from around the world we’ll never even meet. Kids who are living healthier, fuller lives because of the knowledge we share. We know it takes a Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research. Anywhere.

Ask anyone with a Nationwide Children’s badge what they do for a living. They’ll tell you it’s More Than a Job. It’s a calling. It’s a chance to use and grow your talent to make an impact that truly matters. Because here, we exist simply to help children everywhere.

Nationwide Children’s Hospital. A Place to Be Proud.

  • Cross-domain information modeling in interdisciplinary teams between multiple stakeholders, including the ClinGen Data Platform team and the VICC Meta-Knowledgebase team

  • Leading developer teams to implement the above knowledge models and develop informatics tools for tertiary analysis

  • Working with clinical stakeholders and developers at IGM to build platforms compatible with genomic knowledge standards from the Global Alliance for Genomics and Health and clinical standards organizations (e.g. AMP/ASCO/CAP cancer variant classification criteria)

  • Researching methodologies for applying structured genomic knowledge for scalable tertiary analysis and genome interpretation

  • Writing scientific manuscripts on above activities and assisting in grant writing



  • PhD in relevant discipline (e.g. genetics, bioinformatics, computer science)


  • 2+ years of postdoctoral experience in bioinformatics and tertiary analysis

  • Excellent verbal and written communication skills

  • Experience in information & data modeling

  • Knowledge and experience with following domains desirable: Biomedical ontologies, Genomic knowledge resources, Python programming language, Distributed version control systems (e.g. git + GitHub), Collaborative requirements gathering, Product development

EOE M/F/Disability/Vet

Requisition ID: 2021-31811

External Company Name: Nationwide Children's Hospital

External Company URL: