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Arranta Bio Principal Scientist, mRNA Process Sciences in Boston, Massachusetts

Job Descriptions:


Arranta Bio is a visionary contract development and manufacturing organization (CDMO) that partners with companies seeking to develop and manufacture complex biological drugs and innovative therapies. Our dedicated team, state-of-the-art facilities, and unparalleled resources are crucial for advancing products from development to commercial launch. Our vision is to be the trusted and innovative CDMO partner for advanced therapy pioneers, so that we can bring life-changing therapeutics to patients. We partner with our clients to make treatments that can benefit vast patient populations, working across many indications. Arranta Bio’s mission is to change healthcare through our intrepid and daring team engaging with clients to develop, manufacture, and supply breakthrough therapies that transform lives. Arranta Bio continues to expand capacity and development and manufacturing services across multiple sites with technology platforms designed to meet the evolving demands of our clients and partners.


Arranta hires people who are committed and passionate to the goal of bringing life enhancing products to patients. We want top talent who will render ideas and a relentless desire towards accomplishing our mission; when a job becomes a passion, it makes you feel ALIVE.

Here at Arranta Bio, we embrace ALIVE – our core values that we live and breathe daily! We are Agile, Leading, Innovating, Value Creating, and Engaging.

We embrace our challenges as opportunities.

We are empowered to think and act.

We never settle; we strive to improve through purposeful creativity.

We build aligned teams who learn, grow, and deliver.

We are committed to building strong relationships.

Are you ready to come ALIVE with a daring and intrepid team? Don’t wait another minute; Apply today!


  • Design, development, innovate, and improve in-house and client mRNA manufacturing processes including in vitro transcription, capping, tailing, and/or purification

  • Perform scale-up, technology transfer, process development and characterization for RNA-based products

  • Development/scale-up of in vitro transcription and capping reaction, mRNA purification, in-process analytics, engineering, and the highest attention to detail with regard to laboratory documentation

  • Work cross-functionally with manufacturing, process engineering, analytical development and QC, as well as other departments to delivery on-time and in-full on customer commitments from development to manufacture

  • Represent Arranta in current and prospective client interactions as a subject matter expert and technical lead on client programs

  • Authors, executes, and leads development plans, experimental protocols, and investigations

  • Authors and leads the development of technical/development reports for in-house and client programs including contributions to regulatory submissions

  • Provides training, mentorship, and oversight to other scientific and laboratory staff

  • Professionally handles multiple priorities such that client and company goals are realized

  • Utilized DOE and QbD principles to ensure expedient, robust, and quality processes are deployed

  • Ensure process sciences laboratory and staff maintain a safety-first environment

  • Build, train, lead, ensure a continuously improvement culture with respect to Safety, Quality, Delivery, and cost process

Required Experience:

  • PhD Degree in Biology, Biochemistry, Biophysics, or related field with 5+ years of relevant industry experience

  • B.S. or M.S. Degree in Biology, Biochemistry, Biophysics, or related field with 10+ years of relevant industry experience

  • Experience in development of enzymatic reactions such as in vitro transcription and capping

  • Chromatography and/or TFF experience in the purification of nucleic acids

  • Excellent verbal and written communications skills required.

  • Advanced skills in experimental design (e.g., DoE), data analysis, and presentation

  • Understanding with Quality by Design approach to process development

  • Experience with commercial scale up, large-scale bio-manufacture and cGMP is a plus

  • Ability to independently design experiments, analyze complex data and interpret and present experimental results, required

Demonstrated leadership and critical thinking skills and the ability to effectively motivate and manage a team in a fast-paced work environment.


The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  • While performing the duties of this job, the employee is frequently required to stand; sit; use hands to finger, handle, or feel; reach with hands and arms; and talk or hear.

  • The employee is occasionally required to walk; climb or balance; and stoop, kneel, crouch, or crawl.

  • The employee must frequently lift and/or move up to 10 pounds and occasionally lift and/or move up to 25 pounds.

  • Specific vision abilities required by this job include close vision, and ability to adjust focus.

  • Some limited travel may be required

  • The employee will be required to communicate using telephone and e-mail.


COVID19 Vaccine required to come on site; Individuals seeking an exemption from this requirement for medical or religious reasons should reach out to Human Resources for an accommodation.

Keyword: Nucleic Acids, Process Sciences, Biotech


  • Phone reimbursement policy for qualified individuals

  • Free parking

  • Highly competitive healthcare with many plan options:

  • Medical (HMO/PPO/EPO)

  • Dental

  • vision

  • Flexible Spending Accounts for medical expenses and dependent care expenses

  • Up to 10 weeks of 100% paid maternity leave

  • 2 weeks of 100% paid paternity, domestic partner, & adoption leave

  • Educational assistance program

  • 401k (traditional and Roth offered) with 100% match on first 5% deferred.

  • A suite of Arranta Bio paid insurance coverage, including life insurance, short-term and long-term disability

  • Voluntary legal assistance plan

  • Employee Referral program

  • Competitive PTO plan, in addition to 10 company paid holidays (includes 2 floating holidays)

From: Arranta Bio